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Hot Chili

February 2nd, 2009 No comments

Hot Chili

Relieving the pain of surgery Hot Chili Peppers

The anticipated pain of surgery, and even post-operative pain is to maintain a large number of patients to go for that much needed treatment. Although anesthesia has been effective to keep a patient asleep, immobile, and pain during complicated surgeries difficult — can prevent the recurrence of pain once the patient is awake.
Due to the limitations of anesthesia, the medical research community and has been seeking a replacement or appropriate alternative. Recently, scientists have conducted experiments on substances that are used to make hot sauce. Surgeons have tried to use chemical which gives the peppers their "heat" as an experimental anesthetic directly by pouring the substance into open wounds during knee replacement and a few other operations very painful. The experiments made use of an ultra-purified version of capsaicin to avoid infection. The volunteers were submitted under anesthesia so they do not feel the initial burn.

Surgical treatment exposed nerves with a high dose of capsaicin were numb for weeks, so that patients suffer less pain and require fewer narcotic painkillers as they heal. According to Dr. Eske Aasvang, a pain specialist in Denmark who is testing the substance, "We wanted to exploit this numbness."
For centuries, peppers have been part of folk remedy and heat-inducing capsaicin creams are a cure family pharmacy for muscle spasms. Today, however, the spice is also commercially "hot" because of research showing how capsaicin Key objectives of pain sensitive cells in a unique way. Apart from the attempt to s California-based Anes Inc. to take advantage of that burn for more focused pain relief, Harvard University researchers are also mixing capsaicin with another anesthetic drug in the hopes of developing epidurals that are not confined to women the bed during childbirth, or dental injections that do not numb the whole mouth. At the National Institutes of Health, scientists hope that by next year, which may begin testing in advanced cancer patients a capsaicin variant that is 1,000 times more powerful, to see if it can zap their intractable pain.

Nerve cells that felt a kind of long-term throbbing pain contain a receptor called TRPV1. Capsaicin binds to this receptor and is working to produce a calming action on specific receptors of pain fibers.
These so-called C neurons also sense heat, so the capsaicin burn. But when TRPV1 opens, lets extra calcium inside cells until the nerves become overloaded and shut down. That's the numbness. "It just requires a new vision … the stimulation of this receptor in turn discoveries cell therapy in a hunt, "says Dr. Michael Iadarola NIH.
At a meeting of the American Society of Anesthesiologists, Aasvang reported that forty-one men were tested and underwent open repair of hernia. Capsaicin recipients experienced significantly less pain in the first three days after surgery. Another U.S. study 50 knee replacements, half were treated with capsaicin used less morphine than 48 hours after surgery and experienced fewer pain for two weeks. Several ongoing studies are experimenting with larger doses in more patients to see if the effect is real.
"There is a huge need for better surgical pain relief, "said Dr. Eugene Viscusi, director of Acute Pain Management at Thomas Jefferson University in Philadelphia, Pennsylvania, one of the test sites. "Morphine and its relatives, known as opioid analgesics, surgery is expected. Though essential medicines have serious effects side limit its use. "

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Californication – Red Hot Chili Peppers

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